Biomanufacturing Operation Lead

Future Fields
Full Time
Edmonton, AB
Posted 30+ days ago
Job description
*Are you a biochemist with experience in industrial biomanufacturing? Want to help lead scale-up of the world's first drosophila-based expression system and change the future of biotech?* At Future Fields, we’re changing the world - one fruit fly at a time. We’ve developed a novel insect-based expression platform that allows us to make the world’s most sustainable recombinant proteins. We’re unleashing the next biorevolution. At Future Fields, we are continually learning and evolving. We know we don’t have all the answers, but we try to ask all the questions. We believe in “failing forward” and leveraging our mistakes to help us grow. We never want our team to feel constrained by the status quo and we don’t judge ideas based on where they come from. We actively work to foster a culture of collaboration, innovation and psychological safety through transparency, structure, and open communication. We know it sounds cliche, but every employee really is a valued and equal member of the Future Fields team. Come find your purpose with Future Fields. We are a young and rapidly growing venture backed startup (with support from awesome investors including Bee Partners, Y Combinator, and more). We’ve even had a shoutout from Ironman himself! Joining our team now means you’ll have the opportunity to shape our culture and products, to lead others, and to influence the direction of our company. Perhaps most importantly - you’ll be joining a team that is genuinely energized by this work and the meaningful potential of biotech to change the world. About the role The Biomanufacturing Operations Lead exists to establish and own the manufacturing pillar of our operations, rapidly growing our capacity to consistently produce high quality products. You will leverage your biochemistry expertise and experience in industrial biomanufacturing to take locked-in processes from bench protocol to commercial scale, integrating quality standards (ie. GMP, ISOs) when relevant. This role will evolve heavily over time with the needs of the company. In the near term, the focus will be overseeing the transition of our manufacturing operations from bench scale to pilot-scale commercial manufacturing. This will be a highly hands-on position requiring creativity, project management, and deep technical expertise. You will develop processes at scale and be the lead participant in manufacturing runs. In the long-term, this role will evolve to manage a growing manufacturing team of scientists and technicians in an industrial production facility. The Biomanufacturing Lead will report to our Head of Engineering and work closely and collaboratively with teams across Engineering and Process Development, Protein Biochemistry, Genetics, Cell Sciences and Quality. As a senior member of the Future Fields team, all Leads are responsible for: - Supervising, supporting and training team members.- Developing team-specific strategies to support high-level company goals.- Monitoring progress towards goals and course correcting as required to ensure objectives are met.- Setting and monitoring team OKRs.- Continuously exploring, developing, optimizing, testing, and implementing new methodologies and processes.- Collaborating with other team leads and the executive to ensure cross-functional alignment on work plans, strategies and timelines.- Conducting “hands on” bench work whenever needed to maximize team capacity, optimize methodologies and aggressively progress R&D outcomes. This role owns: - Development, management and execution of Future Field’s biomanufacturing strategy, encompassing the scale-up of processes from bench scale to pilot scale and beyond- Managing a downstream manufacturing department and ensuring execution of production plans, compliance, and project scheduling- Hands-on manufacturing of recombinant protein products at bench, pilot and industrial scales in a quality and regulatory compliant environment- Providing technical and scientific knowledge and supervision to personnel and the overall direction of projects. Act as a technical resource across disciplines and provide critical input to areas around protein biochemistry, industrial biomanufacturing, and downstream process development and optimization- Managing workflows to ensure quality, prioritization, and timeliness. Creating and managing project plans, production and procurement schedules, manufacturing inventory management and overseeing production runs.- Identifying and mitigating risks in downstream manufacturing operations that could negatively impact delivery of safe and efficacious products- Working closely with the site leadership, Quality and Regulatory peers to align with requirements prescribed by different regulatory bodies to ensure compliant efficacious products make it to market- Authoring, reviewing and approving controlled master documents including standard operating procedures, batch records, HACCP plans, material specifications, and validation protocols- Developing innovative processes, hypotheses, and methodologies and expanding company IP within the scale-up environment- Innovating and spearheading the development of downstream process technologies that can result in significant increases in labour and capital efficiency, yield and purity- Assuring Quality success through adoption of quality control measures and systems including GMP and ISO Standards, as required- Generating, collecting, analyzing data and presenting scientific findings at internal and/or external research meetings- Defining how the group will contribute to our discovery strategy to continually improve our protein production capabilities for multiple products- Developing and monitoring performance criteria to allow measurement and continuous improvement of efficiency and quality- Analyzing progress, reporting, and communicating key results to the Head of Engineering (weekly basis) and other relevant colleagues- Reporting and communicating progress towards key metrics and milestones (e.g. Weekly Team meetings or ORK updates) This role assists by: - Supporting recruitment, interviewing and onboarding process of new team members- Maintaining a clean and safe work environment- Support business and corporate development, project evaluation, investor due diligence, and providing technical input on proposal and work plan development- Critically contributing to process/product characterization effort.- Incorporating new technologies into the company and supporting technology integration.- Ensure operations are designed and sourced appropriately to enable the company to achieve ambitious goals- Serving as a key member of the Manufacturing Operations leadership team for the design, construction, and start-up of a new GMP Manufacturing facility for the production of recombinant proteins This role requires: - A BS/MS/PhD in Biological Sciences or Engineering. Graduate degree preferred.- 3+ years of experience in manufacturing of biologics or other protein products in a GMP setting- 3+ years of experience in a leadership role managing Technical Operations, Process Development, and/or GMP Manufacturing Operations for recombinant protein products.- Strong knowledge of Downstream process techniques for protein purification from novel biological sources; ability to determine strategies for improved mass and energy balance.- Hands-on experience in operating and maintaining chromatography system and tangential flow filtration systems- Strong leadership passion to build, lead, and mentor a team- Strong communication, teamwork and relationship building skills across the organization to align with company strategy and sustainability goals- The ability to apply pragmatic, risk-based decision making to the operation- Experience leading a site through Quality audits and/or regulatory inspections- Pride in building teams with state-of-the-art technology capabilities and staying on top of the latest developments in the field- Ability to work independently in a highly dynamic and fast-paced environment to contribute to multiple projects About you You are a problem solver at heart and love the idea of applying your unique knowledge and experiences to a brand new challenge. You are flexible and excited about the prospect of working in a dynamic, ever-changing environment where no two weeks look the same. You possess strong leadership and interpersonal skills, and a demonstrated ability to motivate, influence and gain commitment across levels of an organization. You are a team player and will roll up your sleeves and help out when needed, even if a task lives outside of your daily responsibilities. You are meticulous and organized and can execute your vision, turning big ideas on paper to detailed project plans. You can iterate quickly and understand that the needs of a quickly growing startup evolve over time. Your job will look very different your first month and your sixth month, and you are okay with that! You enjoy collaborating with teammates of diverse backgrounds and areas of expertise to solve a common challenge. About our team Our story and approach to science is anything but conventional. Matt (co-founder/CEO) was a touring punkrock musician who dropped out of University before returning to complete his PhD in cell biology. Jalene (co-founder/COO) is a social researcher by training, previously working on issues from the right to affordable housing to harm reduction. The spark of an idea for our technology came while waiting in line for tiny, Canadian donuts. Our broader team of scientists, engineers, circus performers, restaurateurs, dancers, folk music aficionados, kid parents, pet parents, cyclists, and artists hail from every corner of the world - from small town Alberta to Poland, India, Vietnam and Pakistan. We credit our diverse team and experiences as the key to our success - and we encourage candidates of all identities and backgrounds to apply. FAQs Where is Future Fields located? Our headquarters (office and lab space) is located in downtown Edmonton, Alberta, in a beautiful, freshly renovated warehouse. From the exposed brick to our rooftop patio - it’s not your average lab space. It is central, close to transit and bike lanes, and walking distance to some of the city’s best coffee shops, restaurants and Edmonton’s incredible river valley. Will I like working for a startup? Great question. Startup life is definitely not for everyone. We move quickly. Projects and priorities shift fast. There is a lot of ambiguity and uncertainty at times and we’re not immune to the growing pains of an early stage scale-up. The risk is high, but so is the reward. We promise you will never get bored. You will have fun and learn a lot. You will grow personally and professionally in ways you never imagined (alongside our company). You will be part of something much bigger than yourself and contribute directly to the mission of a team who cares deeply about changing the world for the better. I don’t live in Edmonton. Why would I want to relocate there? Because it’s great! For starters, Edmonton is one of Canada’s sunniest cities with 2299 hours of bright sunshine per year. It’s consistently ranked one of Canada’s most affordable cities to live in and was recently described as Canada’s most exciting culinary city. There’s a festival almost every weekend, North America’s largest mall and the longest stretch of urban parkland on the continent (over 160 km of trails!). There’s something for everyone in Edmonton, and it will be even better with you in it. Any other perks? In addition to joining a collaborative, enthusiastic (and really nice) team of people - there are many! Some include: competitive salary; comprehensive health, dental and vision benefits; flexible paid time off policy; and the office is always stocked with snacks and all the coffee you can drink. Sound like something you are interested in? Here are the next steps: Apply online here! This job posting will remain open until a suitable candidate is found. If it seems like a good fit, next steps will look like this: 1. We will contact you for a casual 30 minute video call.2. We will set up an interview to dive into your technical skills and motivation.3. We’ll arrange another interview to figure out how you fit with our team and culture, and better understand your career trajectory.4. We will speak with two of your references to confirm our assumption that you are, in fact, our next great hire.5. We offer you a job! Job Type: Full-time

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